PROPECIA FOR MEN WITH MALE-PATTERN BALDNESS
// October 29th, 2010 // No Comments » // Hormones
Symptoms of balding are not subtle. Men will note some early hair loss simply by looking in the mirror. Almost all men experience, and accept, some thinning of the hair as they age, but when there is an accelerated hair loss at an early age, men do become concerned. The 1-mg finasteride pill sold under the name of Propecia is prescribed for younger men who are troubled by the distinctive and selective pattern of hair loss, commonly referred to as male-pattern baldness.
The striking observation that scalp hair loss (balding) never occurs in men with low serum DHT levels was the stimulus for this research. Doctors were to determine whether lowering a man’s DHT level would reverse or slow down the rate at which he became bald. Only limited studies have been done on this topic, but those that are available indicate that the 1-mg dose of finasteride (Propecia) does lower serum DHT levels by about 65 percent and slows down the rate of hair loss in men with male-pattern baldness. Hair growth resumes with continued use of Propecia and starts to fill in areas that had started to bald. But proving this turned out to be an unusually onerous task.
Balding studies are more difficult to do than studies on urinary flow and prostate size. To give you an example of how demanding this research is, consider the following. In evaluating the effect of finasteride on prostate symptoms, all investigators had to do was ask their patients to fill out a questionnaire on their patterns of urination and arrange for ultrasound studies to determine prostate size before and after treatment.
To do hair-loss studies, doctors had to identify and mark out a single twoinch circular area on the top of a man’s scalp as the target area. Then at each visit, they had to count one by one each and every hair in that target area before, during, and after treatment. The results of two combined studies involving more than 1,500 men yielded the following. Men who had 876 hairs in the target area before had on average 983 hairs after treatment, for a net gain of 107 hairs after one year. This does not seem like much but may be enough for those who are distressed by their hair loss. Men with male-pattern baldness age 18-41 years who take Propecia seem to be pleased with the results.
Side effects were similar to what was observed when the 5-mg finasteride (Proscar) dose was used to treat BPH. Sexual side effects, including impotence, loss of sex drive (libido), and ejaculatory problems, occur in about 4 percent of men who take finasteride at this lower 1-mg dose. This once again raises questions about the importance of DHT as a sexually significant male hormone.



